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KMID : 0043320090320050685
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Archives of Pharmacal Research
2009 Volume.32 No. 5 p.685 ~ p.692
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A New Acyclic Diterpene Acid and Bioactive Compounds from Knema glauca
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Kawanishi Kazuko
Moriyasu Masataka
Suttisri Rutt
Rangkaew Noppadon
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Abstract
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Investigation of the chemical constituents of the fruits of Knema glauca (Myristicaceae) yielded a new acyclic diterpene acid, named glaucaic acid 4, together with four acylphenols, including 1-(2,6-dihydroxyphenyl) tetradecan-1-one 1, malabaricone A 6, dodecanoylphloroglucinol 7 and 1-(2,4,6-trihydroxyphenyl)-9-phenylnonan-1-one 8, two lignans sesamin 2 and asarinin 3, and a flavan, myristinin D 5. In addition, myristinin A 9 and (±)-7,4’-dihydroxy-3’- methoxyflavan 10 were isolated from its leaves and stems, respectively. When tested against small-cell lung cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines, compounds 1, 6-8 and 10 displayed weak to moderate cytotoxicity. The acylphenols 6-8 displayed antituberculosis activity against the microbe Mycobacterium tuberculosis with MIC values of 25, 50 and 100 μg/mL, respectively, and antiviral activity against herpes simplex virus type 1, with 7 as the most active compound (IC50 = 3.05 μg/mL). Malabaricone A 6 was also active against the malarial parasite Plasmodium falciparum with an IC50 value of 2.78 μg/mL.
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KEYWORD
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Knema glauca, Myristicaceae, Acyclic diterpene acid, Cytotoxicity, Antiviral, Antimalarial
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